Vitamin D

COVID-19 mortality risk correlates inversely with vitamin D3 status, and a mortality rate close to zero could theoretically be achieved at 50 ng/ml 25(OH)D3:  Results of a systematic review and meta-analysis "Regression suggested a theoretical point of zero mortality at approximately 50 ng/ml D3. Conclusions The two datasets provide strong evidence that low D3 is a predictor rather than a side effect of the infection. Despite ongoing vaccinations, we recommend raising serum 25(OH)D levels to above 50 ng/ml to prevent or mitigate new outbreaks due to escape mutations or decreasing antibody activity."

August 28, 2021  Vitamin D and COVID-19. Talk at the Ancestral Health Symposium

Vitamin D helps the body
Vitamin D helps the body

One study involving nearly 8,300 adults enrolled in the UK Biobank study found that those who took vitamin D regularly (daily or weekly) were 34 percent less likely to develop COVID-19 compared to those who did not take vitamin D. This effect was exclusive to supplementation with vitamin D, not other supplements, suggesting a link to vitamin D specifically. Other studies have shown that...   COVID-19 patients who had higher vitamin D levels were 20 times less likely to have a critical outcome versus a mild one, and 8 times less likely to have a severe outcome versus a mild one. ...Among patients with COVID-19, 98.9 percent of those with vitamin D deficiency died; 88 percent of those with vitamin D insufficiency died; and just 4 percent of those with sufficiency died, even after adjusting for age, gender, and comorbidities.

Check out these FMF resources:

Among hospitalized COVID-19 patients, pre-infection deficiency of vitamin D is associated with increased disease severity and mortality.  Pre-infection 25-hydroxyvitamin D3 levels and association with severity of COVID-19 illness.    Amiel A. Dror1,2,Nicole G. Morozov3, Amani Daoud1,2, Yoav Namir2, Yakir Orly4, Yair Shachar1, Mark Lifshitz5, Ella Segal1,2, Lior Fischer1,2, Matti Mizrachi1,2, Netanel Eisenbach1,2, Doaa Rayan1,2, Maayan Gruber1,2, Amir Bashkin2,6, Edward Kaykov2,7Masad Barhoum8, Michael Edelstein2.

May 2021. Children get Kawasaki disease and Multisystem Inflammatory Syndrome triggered by COVID-19. This is straight-out inflammatory immune dysregulation caused by very low vitamin D: https://aminotheory.com/cv19/#2015-Stagi
https://sci-hub.se/10.1007/s10067-015-2970-6 The patients were 21 girls and 58 boys, average age 5.8 years. Their average 25OHD levels were 9.2ng/ml, while age-matched controls averaged 23.3ng/ml. In the patients who developed coronary artery abnormalities, the average 25OHD level was 4.9ng/ml.

Dr. Cole presents data supporting his strong recommendation that everyone take a Vitamin D and magnesium supplements during winter months so that your immune system functions at peak levels. As Dr. Cole says, its not "Cold/Flu  Season" its truly low Vitamin D season due to less Sunlight exposure.  April 5, 2020.

Over 200 Scientists & Doctors Call For Increased Vitamin D Use To Combat COVID-19. Scientific evidence indicates vitamin D reduces infections & deaths. Research shows low vitamin D levels almost certainly promote COVID-19 infections, hospitalizations, and deaths. Given its safety, we call for immediate widespread increased vitamin D intakes.

Dr. Ryan Cole, CEO and Medical Director of Cole Diagnostics regarding Covid, vaccine, & treatments. Mar 26, 2021. Great video! Vitamin D's crucial importance to our health.  Conflict of interest - our government is in bed with pharmaceutical interests.  Remdesivir is no good.  Ivermectin is safe and works against viruses; preventative and decreases death rate by 75% and is used all over the world.

Vitamin D and the Immune System  By Cynthia Aranow, MD, Investigator

Video: Dr. Roger Seheult from MedCram on COVID-19 Vaccines, Vitamin D, and Heat Hydrotherapy. Mar 3, 2021

Text by Dr. Roger Seheult, the co-creator of MedCram "Vitamin D regulates immune function and plays an important role in preventing respiratory tract infections. It activates the innate immune system, eliciting an early antiviral response. The vitamin binds to receptors on neutrophils, macrophages, and natural killer cells and stimulates them to produce microbial peptides that exhibit antiviral activity. Vitamin D also inhibits the production of proinflammatory cytokines, which can play a role in a cytokine storma serious complication of COVID-19. ... A recent study found that regular intake of supplemental vitamin D increases circulating levels of the vitamin and reduces the risk of developing COVID-19 by 34 percent. Vitamin D production in the skin diminishes with age and low sunlight exposure (due to latitude, clothing, or sunscreen), so supplementation is probably the best route for achieving optimal vitamin D status. 

NICE, Vitamin D & Covid-19 February 22, 2021

Vitamin D and COVID 19: The Evidence for Prevention and Treatment of Coronavirus (SARS CoV 2) Dec 10, 2020

Video: What’s the most potent form of vitamin D for critical care?

High-Dose Cholecalciferol Booster Therapy is Associated with a Reduced Risk of Mortality in Patients with COVID-19: A Cross-Sectional Multi-Centre Observational Study.

https://doi.org/10.3390/nu12123799 December 2020 by Stephanie F. Ling, Eleanor Broad, Rebecca Murphy, Joseph M. Pappachan, Satveer Pardesi-Newton, Marie-France Kong, Edward B. Jude

Study: Vitamin D deficiency found in over 80% of COVID-19 patients  Oct, 2020.  By Kiersten Willis, The Atlanta Journal-Constitution.    COVID-19 patients at a hospital in Spain were overwhelmingly found to be deficient in vitamin D, according to a new study.

Researchers discovered 80% of 216 COVID-19 patients at the Hospital Universitario Marqués de Valdecilla had a vitamin D deficiency. Men had lower levels of vitamin D than women and COVID-19 patients with lower levels of vitamin D had increased serum levels of inflammatory markers such as ferritin, a blood protein containing iron, and D-dimer, a protein fragment made when a blood clot dissolves in the body. The latter is usually elevated in COVID-19 patients, according to a July study published in the “Journal of Intensive Care.”

Letter to the British Medical Journal Vaccines, convalescent plasma, and monoclonal antibodies for covid-19 BMJ 2020; 370 doi: https://doi.org/10.1136/bmj.m2722 July 2020


https://pubmed.ncbi.nlm.nih.gov/30282560/
The anti-thrombotic effects of vitamin D and their possible relationship
with antiphospholipid syndrome
 
https://www.mdpi.com/2072-6643/12/3/789
Pathophysiological Role and Therapeutic Implications of Vitamin D in
Autoimmunity: Focus on Chronic Autoimmune Diseases
 
https://pubmed.ncbi.nlm.nih.gov/33123377/
*Vitamin D (1,25-(OH) 2 D 3) Improves Endothelial Progenitor Cells Function
via Enhanced NO Secretion in Systemic Lupus Erythematosus*
 
http://inaactamedica.org/archives/2014/25348181.pdf
 
D Prevents Endothelial Damage Induced by Increased Neutrophil Extracellular Traps Formation in Patients with Systemic Lupus Erythematosus

Stop COVID Cold

New Study - Vitamin D High Dose and COVID-19 Sep, 2020 (with calcium and Vit K) Dr. Mobeen Syed.  With Ivermectine helps prevent Covid19

MedCram - Medical Lectures Explained CLEARLY

Vitamin D Insufficiency May Account for Almost Nine of Ten COVID-19 Deaths

Vitamin D and Ivermectin could be helpful in COVID-19

Experts Weigh in on Vitamin D for COVID-19  by Dr. Joseph Mercola

Calcifediol Treatment and COVID-19-Related Outcomes  22 Jan 2021

By Xavier Nogués University of Barcelona - Department of Internal Medicine, Diana Ovejero  Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES) - IMIM (Hospital del Mar Research Institute), J. M. Quesada-Gomez Universidad de Córdoba - Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Roger Bouillon KU Leuven - Clinical and Experimental Endocrinology, Dolores Arenas Hospital del Mar-IMIM - Department of Nephrology, Julio Pascual Autonomous University of Barcelona - Department of Nephrology, Judith Villar-Garcia Hospital del Mar-IMIM - Department of Infectious Diseases, Abora Rial Universitat Autònoma de Barcelona - Internal Medicine Department, Carme Gimenez-Argente Universitat Autònoma de Barcelona - Internal Medicine Department, ML. Cos Universitat Autònoma de Barcelona - Internal Medicine Department, Jaime Rodriguez-Morera Universitat Autònoma de Barcelona - Internal Medicine Department, Isabel Campodarve Universitat Autònoma de Barcelona - Internal Medicine Department, Robert Guerri-Fernandez Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES) - IMIM (Hospital del Mar Research Institute), Marta Pineda-Moncusí Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES) - IMIM (Hospital del Mar Research Institute), Natalia García-Giralt Autonomous University of Barcelona - Department of Internal Medicine

Calcifediol is a prehormone that is produced in the liver by hydroxylation of vitamin D by the enzyme cholecalciferol 25-hydroxylase. … Calcifediol [25(OH)D3] treatment...  Adjusted results showed a reduced mortality for more of 60%... Higher baseline 25(OH)D levels were significantly associated with decreased mortality (RR 0.40 [95% CI 0.24;0.67]). Age and obesity were also predictors of mortality.

Vitamin D Can Likely End the COVID-19 Pandemic  September 9, 2020

Vitamin D: Production, Metabolism, and Mechanisms of Action. Daniel Bikle, M.D., PhD. 2017

Scientists’ Call to D*action – The Vitamin D Deficiency Epidemic. First issued in 2008, then 2015. 40-75% of the world’s population is vitamin D deficient.